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An A-Z Woman's Guide to Vibrant Health

Appendix C

Diagnostic Tests and Types of Treatments for Women's Health

BREAST HEALTH

Breast Self-examinations
Breast Self-Examination (BSE) does not prevent cancer, but many women discover abnormalities in their breasts during regular home testing. Perform the exam the day after your period ends each month. Or, for non-menstruating women, pick the same day each month. Follow these directions to perform your self-examination:
  • Lie down and put a pillow under your right shoulder. Place your right arm behind your head.
  • Use the finger pads of your three middle fingers on your left hand to feel for lumps or thickening in your right breast. Your finger pads are the top third of each finger. Press firmly enough to know how your breast feels. Learn what your breast feels like most of the time. A firm ridge in the lower curve of each breast is normal. You can either make a circle or move your fingers up and down.
  • Move around the breast the same way each time you do the examination so you are aware of any changes.
  • Switch the pillow to your other shoulder, and repeat with your left breast, using the right-hand finger pads.
  • Repeat the examination of both breasts while standing, with one arm behind your head. The upright position makes it easier to check the upper and outer parts of the breasts (toward your armpit). (You may want to do the standing part of the BSE while you are in the shower. Some breast changes can be felt more easily when your skin is wet and soapy.)
  • Check your breasts for any dimpling of the skin, changes in the nipples, redness, or swelling while standing in front of a mirror right after your BSE each month.
Remember that most women have lumps or lumpy areas in their breasts, so don't panic if you find a lump. Report any changes to your doctor. A clinical examination is very much the same as BSE, except that a trained professional may discover abnormalities that you may find insignificant. Both examinations are considered important in detecting cancers early.

Mammogram
Every October, during Breast Cancer Month, national campaigns encourage you to "prevent" breast cancer by having your annual mammogram. A mammogram does not prevent breast cancer. It is a diagnostic tool, albeit, as we are discovering, not the most effective one.

Danish researchers reviewed seven randomized, controlled mammogram trials that supported the benefits of mammography in reducing the rate of death from breast cancer. They found that, out of the seven trials, five were so flawed they could not be considered useful; the two remaining trials also had problems. Researchers determined that mammograms had no effect on reducing deaths due to breast cancer. Published in the Journal of the National Cancer Institute (JNCI), a more recent study that followed over 40,000 women between the ages of 50 and 59 found mammograms do not reduce death rates from breast cancer any better than a simple breast exam.

Mammogram Concerns
The chance of receiving a false positive from mammography is substantial (meaning you have been diagnosed with a cancer when there is none), according to the JNCI.Women in their 40s are at higher risk of false positives due to dense breast tissue. Women who have been taking hormone replacement therapy (estrogen and progestins) have much denser breast tissue, making it difficult to detect abnormal tissue.

A study published in the Journal of the American Medical Association found that women age 70 and older had little to no benefit from regular mammograms. The Lancet reported that breast compression, which occurs during mammography, may cause tumors to rupture, spreading cancer cells.

The safety of repeated ionizing radiation from mammograms has been questioned amid concerns that it may increase the risk of breast cancer.

What's a woman to do? Researchers reported to the 39th Annual Meeting of the American Society of Oncology that Magnetic Resonance Imaging (MRI) offered, by far, the highest sensitivity for diagnosing breast cancer - with the lowest rate of unnecessary biopsies. An MRI uses magnetic energy, not X-rays, to view the breast tissue. They found that MRIs provided 96.1 percent accuracy in reporting positive results, compared to mammography (42.8 percent accurate) and ultrasound (41 percent accurate). We need to insist on better detection methods. Ask your doctor about MRI as an alternative to mammogram. Women should have a baseline breast MRI performed at 40 and then start annual MRIs at age 50.

Thermography
Another promising screening tool is thermography, which is less expensive and sometimes easier to obtain than an MRI.

In order to survive, a cancer tumor has to develop a supply of nutrients. In the early stages, it does this by stealing blood supply and nutrients from nearby cells. This process of angiogenesis continues until the blood cells form tiny capillaries that reach the tumor and start the supply of oxygen and nutrients that fuels rapid growth of the cancer. As the cancer grows, it forms a lump that can be felt during a clinical exam or seen on mammogram, but, long before a lump is felt, heat is produced that can be detected via thermography.

All of this activity within the breast causes changes in the surface temperature of the skin. Thermography, or infrared imaging, is a non-invasive, painless technique that can indicate breast abnormalities, including benign tumors, cancer, fibrocystic breast disease, mastitis or other health issues, at very early stages. In fact, sensitive thermographic equipment is able to detect potential cancers at the stage where blood is pooling near the tumor site. Although thermography is not able to pinpoint the exact location of a tumor, it is extremely useful as a predictor of future cancer risks and, combined with other tests, could help to prevent invasive tumor growth.

During the procedure, a woman sits in a cool room, and removes her clothing from the waist up. Although her skin temperature will drop and blood activity will slow, cancerous and pre-cancerous cells are highly active and operate independent of the nervous system. As a result, these areas will continue to produce heat that will be captured by the sensitive infrared camera. Thermography is effective for detecting angiogenesis in dense breast tissue, so it is suitable for young women as well. Annual thermograms should become part of every woman's breast-health protection strategy especially if you have decided not to have a mammogram or MRI.

REPRODUCTIVE HEALTH

PAP test
A Papanicolaou Test (PAP) should be performed annually after age 18 or before, if the woman is sexually active, and/or taking the birth control pill. The PAP test, also called the PAP smear, is a diagnostic test used to detect abnormal cell growth on the cervix. During this test a speculum is inserted into the vagina and the cells of the cervix are gently scraped off to be examined. This test does not hurt.

Cancer of the cervix develops when the cells on the surface of the cervix divide and grow uncontrollably. It takes years for this cancer to develop and during this time, normal cells change. This change can be detected by a PAP test. We call these abnormal cells which have not become cancerous dysplasia. Mild dysplasia can develop into severe dysplasia, and then cancer, if left untreated.

HPV and abnormal PAP tests: Human papilloma virus, a virus that causes the growth of warts, is often associated with cancer of the cervix and/or dysplasia, chronic urinary tract infections, vaginosis and vaginitis. HPV is considered the most common sexually transmitted disease. It should not be confused with sexual promiscuity; women who have had the same partner for 20 years can contract HPV. Women who have abnormal PAP tests should also be tested for HPV. Of the more than 70 HPV types that have been identified, about 30 infect the cervix. More often an abnormal PAP test is a result of hormonal changes (women on the Pill have a higher rate of abnormal PAP tests), menopause, douching, infection, Candida overgrowth and irritation or inflammation.

Classification of PAP test results
There are two classification methods commonly in use today: the Bethesda System and the CIN Grading System.

Bethesda System:
  • ASCUS (atypical squamous cells of undetermined significance)- Borderline, some abnormal cells
  • LGSIL (low-grade squamous intraepithelial lesions) - Mild dysplasia and cellular changes associated with HPV
  • HGSIL (high-grade squamous intraepithelial lesions) - Moderate to severe dysplasia, precancerous lesions and carcinoma in-situ (preinvasive cancer that involves only the surface cells)
CIN Grading System: CIN stands for Cervical Intraepithelial Neoplasia. This system grades the degree of cell abnormality numerically. Atypia - correlates with ASCUS
CIN I - mild dysplasia and correlates with LGSIL
CIN II - moderate dysplasia and correlates with HGSIL
CIN III - severe dysplasia and correlates with HGSIL
Carcinoma in-situ
Cervical cancer

To find out how to normalize PAP smears, see Cervical Dysplasia.

Ultrasound
Any type of abnormal bleeding or pelvic pain should be evaluated with a pelvic ultrasound (sonography). An ultrasound scan uses high-frequency sound waves that are sent to the body part being examined; these waves are reflected back and displayed on a monitor screen. Pelvic sonography is used to examine the pelvic cavity, ovaries, uterus, endometrium, fallopian tubes, bladder, kidneys and ureters. It is also used to evaluate infertility and to monitor fetal health during pregnancy. Pelvic ultrasounds can be performed vaginally (vaginal ultrasound) or externally, on the belly. Women are asked to consume plenty of water before the procedure so the sound waves can bounce off the bladder for the best possible image.

TREATMENT

Hysterectomy
A hysterectomy is the surgical removal of the uterus, the organ that holds a baby during pregnancy. With over 772,000 operations annually in the U.S. and 60,000 in Canada, hysterectomy is the second most common surgery performed on women, after cesarean section. Before the age of 60, one in three American women will have had a hysterectomy. In Canada, the number is closer to 37 percent. The main reason for hysterectomy is uterine fibroids, which result in heavy periods and anemia, while endometriosis is the second leading cause. Be sure to read the appropriate sections of this book for alternative treatments for these conditions. (See Myomectomy and Uterine Artery Embolization in this section; see also Uterine Fibroids and Endometriosis.)

About 16 percent of hysterectomies are due to uterine prolapse. This occurs when the uterus relocates from its normal position and falls further into the vagina. Prolapse occurs due to weakened ligaments and supportive tissues that frequently result from childbirth, lack of exercise, hormone imbalance at menopause (particularly testosterone deficiency) or obesity. Before considering removal of the uterus, women should try other options including exercise, Kegal exercises or the use of a pessary. Kegel exercises involve squeezing the muscles of the pelvic floor, vagina and buttock muscles. Squeeze, hold and release several times per day. Practice Kegal exercises while urinating. Start and stop the urine stream to improve bladder control while improving internal pelvic muscles.

A pessary is a plastic ring that is inserted into the vagina to support the uterus. Alternatively, less traumatic surgery can tighten the muscles and ligaments around the uterus to help hold it in place. In about ten percent of cases, hysterectomies are performed due to cancers of the reproductive tract.

Many believe that the uterus is a useless organ after a woman has finished having babies. Evidence shows that the uterus plays a role in immune function - it produces the prostaglandins responsible for a variety of physiological functions. The uterus helps in prevention of cardiovascular disease through the production of prostacyclin, which prevents blood clots. The uterus also secretes a small amount of estrogen. Women who have had hysterectomies also appear to be at increased risk of osteoporosis and osteoarthritis. Hysterectomy also impacts libido: in some women the removal of the uterus causes an abrupt end to her sex drive. In fact, particularly in the case of hysterectomy due to prolapsed uterus, research shows that 50 percent of hysterectomies end sexual intercourse permanently. The reason for this can be due to the surgeon damaging nerves or inhibiting blood flow to the clitoris or pelvic region.

Surgical Risks: Any surgery has risks, but women who are obese, or who have high blood pressure, diabetes or other chronic conditions are at increased risk. Complications of surgery include damage and scarring of surrounding internal organs such as the ureters (tubes which carry urine from the bladder to the kidneys), the rectum and the bladder. Deep vein thrombosis involves blood clots that form in the legs but break free and move to the lungs where they can get trapped, causing a potentially fatal embolism. Women who have hysterectomies before menopause may suddenly experience severe menopause symptoms. (See Menopause)

Types of Hysterectomy: With the exception of cancer treatment, hysterectomy should only be performed after you have exhausted all of the options discussed in this book. If you must have a hysterectomy, discuss all of your concerns and evaluate all your choices before proceeding. Also, find an skilled surgeon.
  • Complete or Total Hysterectomy: Also known as a pan-hysterectomy, this is the most commonly performed operation. It involves the removal of the entire uterus, with or without the ovaries. Most women think a total hysterectomy means the removal of the ovaries, but that is false.

  • Partial Hysterectomy: Also known as a supracervical hysterectomy, this surgery leaves leaves the cervix and the ovaries in place; only the uterus is removed.

  • Bilateral Salpingo-oophorectomy: This procedure removes the ovaries and fallopian tubes on both sides of the uterus. This can be done with or without the removal of the uterus.

  • Radical Hysterectomy: As its name implies, this procedure removes the uterus, the cervix, the ovaries, the upper part of the vagina and other supporting tissues.
Procedure: A hysterectomy can be performed either with an abdominal incision or through the vagina. During an abdominal hysterectomy, the surgery is performed through an incision in the abdomen. Surgeons may be able to use a bikini-line incision just above the pubic bone, but often the incision is made vertically.

Vaginal hysterectomies are performed through the vagina. In this form of surgery the cervix is removed as well. Vaginal hysterectomy patients have shorter recovery times because there is no abdominal incision.

LAPAROSCOPY
Laparoscopically assisted vaginal hysterectomies involve the use of a small viewing tube (a laparoscope) through an incision in the abdominal wall. Laparoscopy, where an incision is made in the bellybutton, is done for many types of female conditions, including the diagnosis or removal of endometriosis, ovarian cysts or to evaluate unexplained pelvic pain. During a laparoscopy, usually a very tiny incision is made in the bellybutton and another at the side of the abdomen and one just above the pubic bone. One is for the laparoscope and the others for the surgical instruments. The abdomen is filled with air for ease of viewing.

MICROWAVE ENDOMETRIAL ABLATION (MEA)
Microwave ablation is currently being studied by the medical community as an alternative to surgery for a variety of conditions including heart surgeries as well as a method of treating liver tumors, prostate cancer and breast cancer. In fact, a study published in 2003 showed that microwave ablation was able to halt the growth of early-stage breast tumors in 68 percent of women tested. While still in its infancy as a treatment for breast cancer, microwave endometrial ablation has gained wide acceptance as an alternative to hysterectomy for women with fibroids and menorrhagia (heavy menstrual bleeding).

MEA uses high-frequency microwave energy to heat and destroy the lining of the uterus, or the endometrium. Before microwave endometrial ablation is performed, women are given hormones to further thicken the uterine lining. Then, to prevent perforating the uterus, a woman typically undergoes an ultrasound to determine the minimal thickness of the uterine wall. During the procedure, the cervix is dilated and the doctor inserts a wand-like device into the uterine cavity. The surgeon then moves the applicator around the uterus to destroy the lining. The temperature of the device is strictly monitored, and has an automatic shut-off valve if temperature rises too high. The procedure is carried out under local or general anesthetic and typically takes less than ten minutes to complete. The uterus no longer functions as it used to and pregnancy cannot occur once this treatment has been completed.

MEA has a shorter recovery time than hysterectomy, and the uterus is not removed from the body. Similar to hysterectomy, MEA is not an option for women who are considering pregnancy.

Myomectomy
Uterine fibroids affect a vast number of women. Many exhibit no symptoms, while others have pain or abnormal bleeding. (See Uterine Fibroids) Although hysterectomy is often the first choice to deal with the problem, a less invasive procedure called myomectomy surgically removes the fibroids but leaves the uterus intact. A method called hysteroscopic resection can remove fibroids located inside the uterus through the cervix without the need for an incision. Some fibroids lodged partially in the wall of the uterus and partially in the uterine cavity can also be removed using this procedure. Laparoscopy can often treat fibroids on the outside of the uterus. Larger fibroids can be removed through abdominal surgery, which has a healing time similar to a hysterectomy, but again, leaves the uterus in place. Myomectomy is the recommended treatment for infertility caused by the uterine fibroids in women still wishing to conceive.

Uterine Artery Embolization
A relatively new procedure, uterine artery embolization (UAE) is used to cut off the blood supply to the arteries that feed the fibroid. Small particles of polyvinyl alcohol about the size of a grain of sand are injected into the arteries, and the blockage causes the uterine fibroid to shrink in size or die and symptoms improve. The particles are locked into the vessels so they do not travel through the body. This procedure is not readily available in all communities and there have been reports of emergency hysterectomies having to be performed as a side effect of UAE. Because the long-term effects are not yet known, women considering pregnancy are not suitable candidates for UAE.

THYROID HEALTH

Thyroid Stimulating Hormone (TSH) thyroid test
Laboratory Tests: TSH, T3 and T4. The normal levels for the TSH test are so broadly defined that most patients with functional problems are not clinically diagnosable. Yet it takes very little change in the pituitary stimulating hormone TSH to cause dramatic changes in thyroid function. It is a mystery why the allopathic definition of the normal range for TSH is so wide, given the extreme sensitivity of the thyroid to even minute variations in TSH levels.

Many people suffer with mild or sub-clinical low thyroid function. Their thyroid stimulating hormone (the hormone that stimulates the thyroid to make thyroid hormones) is greater than 2.0 IU/ml but less than the 5.5 IU/ml level indicative of hypothyroidism. As such, these people contend with the many symptoms of low thyroid function, but are not being treated with medication. For more information on Thyroid function, see Thyroid. For additional information on T3, please refer to the work of Dr. E. D. Wilson, Wilson's Syndrome: The Miracle of Feeling Well.

Thyroid Basal Temperature Home test
Monitoring your basal temperature is the most sensitive and accurate way to evaluate thyroid function; it is also the simplest and least expensive. The thyroid sets the thermostat for the body and regulates the rate of metabolism in nearly all of the cells. Therefore, the most reliable window on thyroid function is the basic body temperature, or basal temperature.

Some health care practitioners call basal temperature the axillary temperature because it is measured in the armpit. It is measured at the same time every day - as soon as you wake up in the morning, before arising.

LOW THYROID HOME TEST
  • Your basal body temperature, meaning the temperature of your body at rest, is the most sensitive test of thyroid function. Note: Menstruating women must perform the test on the second, third and fourth days of menstruation. Men and postmenopausal women can perform the test any time.
  • Take the test as soon as you wake up because it is important to take your temperature after you have had adequate rest.
  • Before going to sleep, if you are not using a digital thermometer shake a regular thermometer to below the 95 degree mark and place it by your bed (ready to be used in the morning).
  • Immediately upon waking, before you get out of bed, place the thermometer in your armpit (hold for a count of 10 if you are using a regular thermometer). Hold your elbow close to your side to keep the thermometer in place.
  • Read and record the temperature and date.
  • Repeat the test for three mornings (preferably at the same time every day).
  • A reading between 97.6 and 98.2 degrees F is normal. Readings below 97.6 may indicate hypothyroidism.


The research on basal temperature as the most accurate measurement for thyroid function was done by Dr. Broda Barnes, who has more than 40 years of clinical experience with thyroid patients. Look for both books authored by Broda Barnes, Heart Attack Rareness in Thyroid-Treated Patients and Hypothyroidism: The Unsuspected Illness.